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10010302-100Inhibits CKII (IC50 range of 4-10 µM), Cdk7 (IC50 = ~20 µM), Cdk8 (IC50 = ~20 µM), and Cdk9 (IC50 = 3 µM) inhibits elongation during RNA polymerase II transcription triggers p53-dependent apoptosis of human colon
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10010302-250Inhibits CKII (IC50 range of 4-10 µM), Cdk7 (IC50 = ~20 µM), Cdk8 (IC50 = ~20 µM), and Cdk9 (IC50 = 3 µM) inhibits elongation during RNA polymerase II transcription triggers p53-dependent apoptosis of human colon
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10010302-50Inhibits CKII (IC50 range of 4-10 µM), Cdk7 (IC50 = ~20 µM), Cdk8 (IC50 = ~20 µM), and Cdk9 (IC50 = 3 µM) inhibits elongation during RNA polymerase II transcription triggers p53-dependent apoptosis of human colon
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18907-1Selectively activates hM3Dq (EC<sub>50</sub> = 1.7 nM), a DREADD derived from the human muscarinic acetylcholine M3 receptor.
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18907-10Selectively activates hM3Dq (EC<sub>50</sub> = 1.7 nM), a DREADD derived from the human muscarinic acetylcholine M3 receptor.
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18907-5Selectively activates hM3Dq (EC<sub>50</sub> = 1.7 nM), a DREADD derived from the human muscarinic acetylcholine M3 receptor.
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18884-1A butyrophenone that acts as an antagonist at dopamine receptors (Kis = 0.25 and 0.84 nM at human D2 and D4) less potently inhibits the human voltage-gated potassium channel (IC<sub>50</sub> = 32 nM).
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18884-100A butyrophenone that acts as an antagonist at dopamine receptors (Kis = 0.25 and 0.84 nM at human D2 and D4) less potently inhibits the human voltage-gated potassium channel (IC<sub>50</sub> = 32 nM).
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18884-50A butyrophenone that acts as an antagonist at dopamine receptors (Kis = 0.25 and 0.84 nM at human D2 and D4) less potently inhibits the human voltage-gated potassium channel (IC<sub>50</sub> = 32 nM).
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18884-500A butyrophenone that acts as an antagonist at dopamine receptors (Kis = 0.25 and 0.84 nM at human D2 and D4) less potently inhibits the human voltage-gated potassium channel (IC<sub>50</sub> = 32 nM).
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70645-10DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2.
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70645-25DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2.