Biologically Active Small Molecules

DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2.

DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2.

A time-dependent, dual inhibitor of 5&alpha-reductase (apparent Kis = 17 and 4.3 nM at 10 and 30 minute reaction times, respectively) that is frequently used in the treatment of benign prostatic hyperplasia.

A time-dependent, dual inhibitor of 5&alpha-reductase (apparent Kis = 17 and 4.3 nM at 10 and 30 minute reaction times, respectively) that is frequently used in the treatment of benign prostatic hyperplasia.

A time-dependent, dual inhibitor of 5&alpha-reductase (apparent Kis = 17 and 4.3 nM at 10 and 30 minute reaction times, respectively) that is frequently used in the treatment of benign prostatic hyperplasia.

A time-dependent, dual inhibitor of 5&alpha-reductase (apparent Kis = 17 and 4.3 nM at 10 and 30 minute reaction times, respectively) that is frequently used in the treatment of benign prostatic hyperplasia.

A selective ERR&beta/&gamma receptor agonist (EC₅₀ = 130 nM) used to potentiate ERR&gamma-induced growth inhibition in LNCaP and DU145 prostate cancer cell lines.

A selective ERR&beta/&gamma receptor agonist (EC₅₀ = 130 nM) used to potentiate ERR&gamma-induced growth inhibition in LNCaP and DU145 prostate cancer cell lines.

A selective ERR&beta/&gamma receptor agonist (EC₅₀ = 130 nM) used to potentiate ERR&gamma-induced growth inhibition in LNCaP and DU145 prostate cancer cell lines.

A selective ERR&beta/&gamma receptor agonist (EC₅₀ = 130 nM) used to potentiate ERR&gamma-induced growth inhibition in LNCaP and DU145 prostate cancer cell lines.

A chemoselective probe for detecting sulfenylated proteins in intact cells using click chemistry.

A chemoselective probe for detecting sulfenylated proteins in intact cells using click chemistry.