Biologically Active Small Molecules

A 13-residue opioid peptide that acts as an endogenous &kappa1b-opioid receptor agonist (Ki = 1.1 nM) has been implicated in antinociceptive functions and has also been used to prime cardiogenesis in pluripotent embryonic stem cells.

A 13-residue opioid peptide that acts as an endogenous &kappa1b-opioid receptor agonist (Ki = 1.1 nM) has been implicated in antinociceptive functions and has also been used to prime cardiogenesis in pluripotent embryonic stem cells.

A xanthine derivative that acts as an adenosine receptor antagonist and phosphodiesterase inhibitor and exhibits bronchodilator and vasodilator effects also inhibits mPGES-1 (IC₅₀ = 200 &microM) and downregulates ABCG2 drug transporter

A xanthine derivative that acts as an adenosine receptor antagonist and phosphodiesterase inhibitor and exhibits bronchodilator and vasodilator effects also inhibits mPGES-1 (IC₅₀ = 200 &microM) and downregulates ABCG2 drug transporter

A xanthine derivative that acts as an adenosine receptor antagonist and phosphodiesterase inhibitor and exhibits bronchodilator and vasodilator effects also inhibits mPGES-1 (IC₅₀ = 200 &microM) and downregulates ABCG2 drug transporter

A xanthine derivative that acts as an adenosine receptor antagonist and phosphodiesterase inhibitor and exhibits bronchodilator and vasodilator effects also inhibits mPGES-1 (IC₅₀ = 200 &microM) and downregulates ABCG2 drug transporter

A methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC₅₀ = 29 nM) inhibits the ERG1, ERG2, and ERG3 isoforms with KD values of 99, 116, and 193 nM,

A methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC₅₀ = 29 nM) inhibits the ERG1, ERG2, and ERG3 isoforms with KD values of 99, 116, and 193 nM,

A methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC₅₀ = 29 nM) inhibits the ERG1, ERG2, and ERG3 isoforms with KD values of 99, 116, and 193 nM,

A methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC₅₀ = 29 nM) inhibits the ERG1, ERG2, and ERG3 isoforms with KD values of 99, 116, and 193 nM,

A natural, potent and irreversible inhibitor of cysteine proteases IC50 values for inhibiting cathepsins K, S, and L, in vitro, are 1.4, 4.1, and 2.5 nM, respectively also inhibits papain, calpain, and cathepsins B and H.

A natural, potent and irreversible inhibitor of cysteine proteases IC50 values for inhibiting cathepsins K, S, and L, in vitro, are 1.4, 4.1, and 2.5 nM, respectively also inhibits papain, calpain, and cathepsins B and H.