Biologically Active Small Molecules

A natural, potent and irreversible inhibitor of cysteine proteases IC50 values for inhibiting cathepsins K, S, and L, in vitro, are 1.4, 4.1, and 2.5 nM, respectively also inhibits papain, calpain, and cathepsins B and H.

A synthetic analog of E-64, a potent and irreversible cysteine protease inhibitor inhibits cathepsin B and L from rat liver with IC50 values of 8.7 and 3.5 nM, respectively.

A synthetic analog of E-64, a potent and irreversible cysteine protease inhibitor inhibits cathepsin B and L from rat liver with IC50 values of 8.7 and 3.5 nM, respectively.

A synthetic analog of E-64, a potent and irreversible cysteine protease inhibitor inhibits cathepsin B and L from rat liver with IC50 values of 8.7 and 3.5 nM, respectively.

A synthetic analog of E-64, a potent and irreversible cysteine protease inhibitor inhibits cathepsin B and L from rat liver with IC50 values of 8.7 and 3.5 nM, respectively.

An irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases at 20-200 &microM arrests human epidermoid carcinoma A431 cells at mitotic metaphase inhibits protease-resistant protein accumulation in scrapie-infected

An irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases at 20-200 &microM arrests human epidermoid carcinoma A431 cells at mitotic metaphase inhibits protease-resistant protein accumulation in scrapie-infected

An irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases at 20-200 &microM arrests human epidermoid carcinoma A431 cells at mitotic metaphase inhibits protease-resistant protein accumulation in scrapie-infected

An irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases at 20-200 &microM arrests human epidermoid carcinoma A431 cells at mitotic metaphase inhibits protease-resistant protein accumulation in scrapie-infected

A calmodulin inhibitor that disrupts the activity of calmodulin-dependent enzymes such as myosin light chain kinase (IC₅₀ = 8 &microM) and phosphodiesterase 1A (IC₅₀ = 0.53 &microM) inhibits P-glycoprotein activity in

A calmodulin inhibitor that disrupts the activity of calmodulin-dependent enzymes such as myosin light chain kinase (IC₅₀ = 8 &microM) and phosphodiesterase 1A (IC₅₀ = 0.53 &microM) inhibits P-glycoprotein activity in

A specific antagonist of the type 4 PGE2 receptor EP4 possesses significant anti-tumor growth activity in multiple preclinical tumor models through modulating myeloid cells.