Biologically Active Small Molecules

A &beta-lactone that stimulates host defense in immune cells by inhibiting cell surface esterases, lipases, and N-formylmethionine aminopeptidases with IC₅₀ values of 0.056, 0.

A potent, selective inhibitor of aldose reductase (IC₅₀ = 47 nM in vitro) used to improve the cytotoxic effects certain anticancer agents inhibits PGF2&alpha and PGE2 production in human endometrial cells (EC₅₀ = 10 &muM).

A potent, selective inhibitor of aldose reductase (IC₅₀ = 47 nM in vitro) used to improve the cytotoxic effects certain anticancer agents inhibits PGF2&alpha and PGE2 production in human endometrial cells (EC₅₀ = 10 &muM).

A potent, selective inhibitor of aldose reductase (IC₅₀ = 47 nM in vitro) used to improve the cytotoxic effects certain anticancer agents inhibits PGF2&alpha and PGE2 production in human endometrial cells (EC₅₀ = 10 &muM).

Formed by the oxidation of ebselen lacks antioxidant acitivity.

Formed by the oxidation of ebselen lacks antioxidant acitivity.

Formed by the oxidation of ebselen lacks antioxidant acitivity.

Formed by the oxidation of ebselen lacks antioxidant acitivity.

Ebselen acts as a glutathione peroxidase mimic and is an excellent scavenger of peroxynitrite with a rate constant of 2 x 106 M&minus1s&minus1. The glutathione peroxidase-like activity of ebselen inhibits cyclooxygenase and lipoxygenases at

Ebselen acts as a glutathione peroxidase mimic and is an excellent scavenger of peroxynitrite with a rate constant of 2 x 106 M&minus1s&minus1. The glutathione peroxidase-like activity of ebselen inhibits cyclooxygenase and lipoxygenases at

Ebselen acts as a glutathione peroxidase mimic and is an excellent scavenger of peroxynitrite with a rate constant of 2 x 106 M&minus1s&minus1. The glutathione peroxidase-like activity of ebselen inhibits cyclooxygenase and lipoxygenases at

A photostable synthetic analog of ATRA that induces differentiation in human pluripotent embryonic stem cells when used within the range of 100 nM-10 &microM.