Biologically Active Small Molecules

A selective inhibitor of PDE4 (IC₅₀ = 72 nM) that antagonizes the Hedgehog signaling pathway activates localized PKA signaling, which, in turn, regulates Gli processing and translocation.

A cell-permeant acetoxymethyl ester of the calcium chelator EGTA.

A dual inhibitor of adenosine deaminase (IC₅₀ = 1.2 &muM in human red blood cells) and PDE2 (IC₅₀s = 0.8 and 2 &muM from human and pig myocardium, respectively, 3.5 &muM in rat hepatocyte, and 5.5 &muM in human platelet).

A dual inhibitor of adenosine deaminase (IC₅₀ = 1.2 &muM in human red blood cells) and PDE2 (IC₅₀s = 0.8 and 2 &muM from human and pig myocardium, respectively, 3.5 &muM in rat hepatocyte, and 5.5 &muM in human platelet).

A dual inhibitor of adenosine deaminase (IC₅₀ = 1.2 &muM in human red blood cells) and PDE2 (IC₅₀s = 0.8 and 2 &muM from human and pig myocardium, respectively, 3.5 &muM in rat hepatocyte, and 5.5 &muM in human platelet).

An inhibitor of the Rac subfamily of Rho GTPases, that binds to Rac1, Rac1b, Rac2, and Rac3 with Kd values of 40, 50, 50, and 250 nM, respectively has inhibitory effects on APP processing, breast cancer cell invasion, and growth of dendritic spines.

An inhibitor of the Rac subfamily of Rho GTPases, that binds to Rac1, Rac1b, Rac2, and Rac3 with Kd values of 40, 50, 50, and 250 nM, respectively has inhibitory effects on APP processing, breast cancer cell invasion, and growth of dendritic spines.

An inhibitor of the Rac subfamily of Rho GTPases, that binds to Rac1, Rac1b, Rac2, and Rac3 with Kd values of 40, 50, 50, and 250 nM, respectively has inhibitory effects on APP processing, breast cancer cell invasion, and growth of dendritic spines.

An inhibitor of the Rac subfamily of Rho GTPases, that binds to Rac1, Rac1b, Rac2, and Rac3 with Kd values of 40, 50, 50, and 250 nM, respectively has inhibitory effects on APP processing, breast cancer cell invasion, and growth of dendritic spines.

A selective EZH2 inhibitor that has activity against both wild-type and Y641F mutant EZH2 (IC₅₀s = 15 and 13 nM, respectively) blocks cellular H3K27 methylation and activates PRC2-specific gene expression decreases proliferation, cell

A selective EZH2 inhibitor that has activity against both wild-type and Y641F mutant EZH2 (IC₅₀s = 15 and 13 nM, respectively) blocks cellular H3K27 methylation and activates PRC2-specific gene expression decreases proliferation, cell

A selective EZH2 inhibitor that has activity against both wild-type and Y641F mutant EZH2 (IC₅₀s = 15 and 13 nM, respectively) blocks cellular H3K27 methylation and activates PRC2-specific gene expression decreases proliferation, cell