Biologically Active Small Molecules

ETYA is a nonspecific inhibitor of cyclooxygenases and lipoxygenases. ETYA inhibits human platelet 12-LO and COX-1 with IC₅₀ values of 4 &microM and 8 &microM, respectively.

A dual inhibitor of MRP-1 and BCRP maximally inhibits MRP-1 in isolated human peripheral blood leukocytes at 200 nM effective against both human BCRP and the mouse homolog, Bcrp1.

A dual inhibitor of MRP-1 and BCRP maximally inhibits MRP-1 in isolated human peripheral blood leukocytes at 200 nM effective against both human BCRP and the mouse homolog, Bcrp1.

A dual inhibitor of MRP-1 and BCRP maximally inhibits MRP-1 in isolated human peripheral blood leukocytes at 200 nM effective against both human BCRP and the mouse homolog, Bcrp1.

A dual inhibitor of MRP-1 and BCRP maximally inhibits MRP-1 in isolated human peripheral blood leukocytes at 200 nM effective against both human BCRP and the mouse homolog, Bcrp1.

Elaidic acid is the 9-trans isomer of oleic acid. It is a monounsaturated trans-fatty acid which can be found in partially hydrogenated cooking oils.

Elaidic acid is the 9-trans isomer of oleic acid. It is a monounsaturated trans-fatty acid which can be found in partially hydrogenated cooking oils.

Elaidic acid is the 9-trans isomer of oleic acid. It is a monounsaturated trans-fatty acid which can be found in partially hydrogenated cooking oils.

Elaidic acid is the 9-trans isomer of oleic acid. It is a monounsaturated trans-fatty acid which can be found in partially hydrogenated cooking oils.

A macrodiolide antibiotic that displays anti-protozoal activity against both Plasmodium and Trypanosoma (IC₅₀s = 370 and 460 ng/ml, respectively) and cytotoxicity against MRC-5 cells (IC₅₀ = 870 ng/ml) enhances the anti-fungal

A macrodiolide antibiotic that displays anti-protozoal activity against both Plasmodium and Trypanosoma (IC₅₀s = 370 and 460 ng/ml, respectively) and cytotoxicity against MRC-5 cells (IC₅₀ = 870 ng/ml) enhances the anti-fungal

A non-competitive NMDA receptor antagonist that inhibits neuronal calcium channel currents selective for NR2B subunit-containing receptors (IC₅₀ = 1 &microM), displaying greater than 100-fold selectivity for NR2B over NR2A and NR2C