Biologically Active Small Molecules

A cytidine analog with an unnatural &beta-L structural configuration that inhibits reverse transcriptase, preventing replication of HIV-1 (EC₅₀ = 10-20 nM) and hepatitis B (EC₅₀ = 10-40 nM).

A cytidine analog with an unnatural &beta-L structural configuration that inhibits reverse transcriptase, preventing replication of HIV-1 (EC₅₀ = 10-20 nM) and hepatitis B (EC₅₀ = 10-40 nM).

A cytidine analog with an unnatural &beta-L structural configuration that inhibits reverse transcriptase, preventing replication of HIV-1 (EC₅₀ = 10-20 nM) and hepatitis B (EC₅₀ = 10-40 nM).

An orally-active ACE inhibitor (IC₅₀ values range from 2 to 800 nM).

An orally-active ACE inhibitor (IC₅₀ values range from 2 to 800 nM).

An orally-active ACE inhibitor (IC₅₀ values range from 2 to 800 nM).

An orally-active ACE inhibitor (IC₅₀ values range from 2 to 800 nM).

The active metabolite of the ACE inhibitor, enalapril inhibits ACE activity with an IC₅₀ value of 5.8 nM in vitro.

The active metabolite of the ACE inhibitor, enalapril inhibits ACE activity with an IC₅₀ value of 5.8 nM in vitro.

The active metabolite of the ACE inhibitor, enalapril inhibits ACE activity with an IC₅₀ value of 5.8 nM in vitro.

The active metabolite of the ACE inhibitor, enalapril inhibits ACE activity with an IC₅₀ value of 5.8 nM in vitro.

A selective inhibitor of B-RafV600E mutant melanoma cell proliferation (EC₅₀ = 4 nM) with little activity against wild-type B-Raf or a panel of 100 other kinases (IC₅₀s = 900 nM) decreases phosphorylation of the B-Raf