Biologically Active Small Molecules

Inhibits the Pdr5p in yeast, augmenting, at concentrations as low as 0.8 &muM, the ability of cerulenin or cycloheximide to impair cell proliferation inhibits ACAT (IC₅₀ = 113 &muM), blocking cholesteryl ester formation.

Inhibits the Pdr5p in yeast, augmenting, at concentrations as low as 0.8 &muM, the ability of cerulenin or cycloheximide to impair cell proliferation inhibits ACAT (IC₅₀ = 113 &muM), blocking cholesteryl ester formation.

A cyclohexadepsipeptide that has been shown to induce apoptosis in several cancer lines (EC₅₀s &le 10 &microM) and to decrease the activation of the cell proliferation kinase, ERK (p44/p42) inhibits the multi-drug resistance

A cyclohexadepsipeptide that has been shown to induce apoptosis in several cancer lines (EC₅₀s &le 10 &microM) and to decrease the activation of the cell proliferation kinase, ERK (p44/p42) inhibits the multi-drug resistance

A mixture of cyclohexadepsipeptides commonly isolated from fungi that act as ionophores, forming pores in cellular membranes to allow selective ion transport exhibits antimicrobial activity against a variety of eukaryotic and prokaryotic genera,

A mixture of cyclohexadepsipeptides commonly isolated from fungi that act as ionophores, forming pores in cellular membranes to allow selective ion transport exhibits antimicrobial activity against a variety of eukaryotic and prokaryotic genera,

A depsipeptide antibiotic that contains two unusual amino acids (N-methylalanine and 4-methylproline) and features a pentaenone side chain effective against Gram-positive bacteria, including methicillin-resistant S. aureus (MIC = 25 &microg/ml),

A depsipeptide antibiotic that contains two unusual amino acids (N-methylalanine and 4-methylproline) and features a pentaenone side chain effective against Gram-positive bacteria, including methicillin-resistant S. aureus (MIC = 25 &microg/ml),

A fluoroquinolone that prevents bacterial growth by interfering with DNA replication, inhibiting bacterial DNA gyrase (IC₅₀ = 126 &microg/ml) and topoisomerase IV (IC₅₀ = 26.5 &microg/ml) used to enhance the production of

A fluoroquinolone that prevents bacterial growth by interfering with DNA replication, inhibiting bacterial DNA gyrase (IC₅₀ = 126 &microg/ml) and topoisomerase IV (IC₅₀ = 26.5 &microg/ml) used to enhance the production of

A fluoroquinolone that prevents bacterial growth by interfering with DNA replication, inhibiting bacterial DNA gyrase (IC₅₀ = 126 &microg/ml) and topoisomerase IV (IC₅₀ = 26.5 &microg/ml) used to enhance the production of

A non-enzymatic, free radical peroxidation product of arachidonic acid acts as a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 31 and 54 nM, respectively.