Biologically Active Small Molecules

An internal standard for the quantification of ent-8-iso-15(S)-PGF2&alpha by GC- or LC-MS.

The opposite enantiomer of corey PG-lactone diol, a versatile, chiral intermediate used in the preparation of PGs and PG analogs.

The opposite enantiomer of corey PG-lactone diol, a versatile, chiral intermediate used in the preparation of PGs and PG analogs.

The opposite enantiomer of corey PG-lactone diol, a versatile, chiral intermediate used in the preparation of PGs and PG analogs.

Enzymatically-derived PGE2 is an optically pure compound whereas PGE2 derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture. Ent-PGE2 is the opposite enantiomer of PGE2.

Enzymatically-derived PGF2&alpha is an optically pure compound whereas PGF2&alpha derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture. Ent-PGF2&alpha is the opposite enantiomer of PGF2&alpha.

A peripherally acting, selective and reversible COMT inhibitor with IC₅₀ values of 150-300 nM in rat liver (Ki = 145 nM) and 10-20 nM in rat brain tissues decreases 3-OMD levels in the rat brain by 16-52% and prolongs the bioavailability

A peripherally acting, selective and reversible COMT inhibitor with IC₅₀ values of 150-300 nM in rat liver (Ki = 145 nM) and 10-20 nM in rat brain tissues decreases 3-OMD levels in the rat brain by 16-52% and prolongs the bioavailability

A peripherally acting, selective and reversible COMT inhibitor with IC₅₀ values of 150-300 nM in rat liver (Ki = 145 nM) and 10-20 nM in rat brain tissues decreases 3-OMD levels in the rat brain by 16-52% and prolongs the bioavailability

A peripherally acting, selective and reversible COMT inhibitor with IC₅₀ values of 150-300 nM in rat liver (Ki = 145 nM) and 10-20 nM in rat brain tissues decreases 3-OMD levels in the rat brain by 16-52% and prolongs the bioavailability

A potent deoxyguanosine nucleoside analog with antiviral activity selective for hepadnaviruses (EC₅₀ = 3.7 nM against the HBV in cultured 2.2.15 liver cells).

A potent deoxyguanosine nucleoside analog with antiviral activity selective for hepadnaviruses (EC₅₀ = 3.7 nM against the HBV in cultured 2.2.15 liver cells).