Biologically Active Small Molecules

An orally bioavailable, selective inhibitor of EZH2 (Ki = 2.5 nM) blocks H3K27 trimethylation in both wild-type and mutant lymphoma cells (IC₅₀s range from 2-90 nM) induces apoptosis and differentiation specifically in SMARCB1-deleted

An orally bioavailable, selective inhibitor of EZH2 (Ki = 2.5 nM) blocks H3K27 trimethylation in both wild-type and mutant lymphoma cells (IC₅₀s range from 2-90 nM) induces apoptosis and differentiation specifically in SMARCB1-deleted

A mycotoxin that inhibits the activity of HIV-1 integrases (IC₅₀ = 7-20 &microM) reported to nonspecifically inhibit transport of mitochondrial metabolites, which can negatively affect mitochondrial function.

A mycotoxin that inhibits the activity of HIV-1 integrases (IC₅₀ = 7-20 &microM) reported to nonspecifically inhibit transport of mitochondrial metabolites, which can negatively affect mitochondrial function.

Bakuchiol is a prenylated phenolic terpene originally sourced from many plants, including Psoralea coryfolia. Bakuchiol exhibits estrogenic, antibacterial, anti-inflammatory, anti-diabetic, anti-hyperlipidemic, and anti-fibrotic activities.

Bakuchiol is a prenylated phenolic terpene originally sourced from many plants, including Psoralea coryfolia. Bakuchiol exhibits estrogenic, antibacterial, anti-inflammatory, anti-diabetic, anti-hyperlipidemic, and anti-fibrotic activities.

Bakuchiol is a prenylated phenolic terpene originally sourced from many plants, including Psoralea coryfolia. Bakuchiol exhibits estrogenic, antibacterial, anti-inflammatory, anti-diabetic, anti-hyperlipidemic, and anti-fibrotic activities.

An irreversible antitumor agent that induces non-apoptotic cell death selectively in tumor cells expressing the small T oncoprotein and oncogenic Ras (IC₅₀s = 1.25-5 &microg/ml).

An irreversible antitumor agent that induces non-apoptotic cell death selectively in tumor cells expressing the small T oncoprotein and oncogenic Ras (IC₅₀s = 1.25-5 &microg/ml).

An irreversible antitumor agent that induces non-apoptotic cell death selectively in tumor cells expressing the small T oncoprotein and oncogenic Ras (IC₅₀s = 1.25-5 &microg/ml).

An irreversible antitumor agent that induces non-apoptotic cell death selectively in tumor cells expressing the small T oncoprotein and oncogenic Ras (IC₅₀s = 1.25-5 &microg/ml).

A stable, potent analog of erbstatin inhibits EGFR tyrosine kinase in vitro with an IC50 of 0.14 &microg/ml inhibits EGF-stimulated growth in NIH3T3 cells with an IC50 value of 0.5 &microg/ml delays onset of EGF-induced DNA synthesis.