Biologically Active Small Molecules

A stable, potent analog of erbstatin inhibits EGFR tyrosine kinase in vitro with an IC50 of 0.14 &microg/ml inhibits EGF-stimulated growth in NIH3T3 cells with an IC50 value of 0.5 &microg/ml delays onset of EGF-induced DNA synthesis.

A stable, potent analog of erbstatin inhibits EGFR tyrosine kinase in vitro with an IC50 of 0.14 &microg/ml inhibits EGF-stimulated growth in NIH3T3 cells with an IC50 value of 0.5 &microg/ml delays onset of EGF-induced DNA synthesis.

A stable, potent analog of erbstatin inhibits EGFR tyrosine kinase in vitro with an IC50 of 0.14 &microg/ml inhibits EGF-stimulated growth in NIH3T3 cells with an IC50 value of 0.5 &microg/ml delays onset of EGF-induced DNA synthesis.

A cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 &microM) blocks ERK-specific phosphorylation of Rsk-1 and TCF/Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2 completely prevents proliferation of several

A cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 &microM) blocks ERK-specific phosphorylation of Rsk-1 and TCF/Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2 completely prevents proliferation of several

A cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 &microM) blocks ERK-specific phosphorylation of Rsk-1 and TCF/Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2 completely prevents proliferation of several

A tyrosine kinase inhibitor which acts on EGFR, inhibiting EGFR-associated kinase activity (IC50 = 2.5 &microM) and tumor growth in human HN5 tumor xenografts in mice with an ED50 value of 9 mg/kg drug form of Erlotinib, Tarceva&trade, is used to

A tyrosine kinase inhibitor which acts on EGFR, inhibiting EGFR-associated kinase activity (IC50 = 2.5 &microM) and tumor growth in human HN5 tumor xenografts in mice with an ED50 value of 9 mg/kg drug form of Erlotinib, Tarceva&trade, is used to

A tyrosine kinase inhibitor which acts on EGFR, inhibiting EGFR-associated kinase activity (IC50 = 2.5 &microM) and tumor growth in human HN5 tumor xenografts in mice with an ED50 value of 9 mg/kg drug form of Erlotinib, Tarceva&trade, is used to

A tyrosine kinase inhibitor which acts on EGFR, inhibiting EGFR-associated kinase activity (IC50 = 2.5 &microM) and tumor growth in human HN5 tumor xenografts in mice with an ED50 value of 9 mg/kg drug form of Erlotinib, Tarceva&trade, is used to

An isothiocyanate derived from cruciferous vegetables that has significant antiapoptotic and antioxidant effects in various cancer cells.

An isothiocyanate derived from cruciferous vegetables that has significant antiapoptotic and antioxidant effects in various cancer cells.