Biologically Active Small Molecules

A dipyridinyl compound that demonstrates high in vitro and ex vivo selectivity for COX-2 over COX-1.

A dipyridinyl compound that demonstrates high in vitro and ex vivo selectivity for COX-2 over COX-1.

An ATR inhibitor (IC₅₀ = 25 nM) that also inhibits mTOR and DNA-PK (IC₅₀s = 0.6 and 36 nM, respectively) generates replicative stress, leading to chromosomal breakage in the presence of conditions that stall replication forks.

An ATR inhibitor (IC₅₀ = 25 nM) that also inhibits mTOR and DNA-PK (IC₅₀s = 0.6 and 36 nM, respectively) generates replicative stress, leading to chromosomal breakage in the presence of conditions that stall replication forks.

An ATR inhibitor (IC₅₀ = 25 nM) that also inhibits mTOR and DNA-PK (IC₅₀s = 0.6 and 36 nM, respectively) generates replicative stress, leading to chromosomal breakage in the presence of conditions that stall replication forks.

A synthetic catalytic scavenger of reactive oxygen species, with reduced activity compared to EUK 8 and EUK 134.

A synthetic catalytic scavenger of reactive oxygen species, with reduced activity compared to EUK 8 and EUK 134.

A synthetic catalytic scavenger of reactive oxygen species, with reduced activity compared to EUK 8 and EUK 134.

A synthetic catalytic scavenger of reactive oxygen species, with reduded activity compared to EUK 8 and EUK 134.

A synthetic catalytic scavenger of reactive oxygen species, with reduded activity compared to EUK 8 and EUK 134.

A salen-manganese complex with catalase and SOD mimetic activity.

A salen-manganese complex with catalase and SOD mimetic activity.