Biologically Active Small Molecules

A third generation, irreversible steroidal aromatase inhibitor (Ki = 10.2 nM Kinact = 26 nM) that induces aromatase degradation, which leads to a decrease in estrogen levels in plasma.

A third generation, irreversible steroidal aromatase inhibitor (Ki = 10.2 nM Kinact = 26 nM) that induces aromatase degradation, which leads to a decrease in estrogen levels in plasma.

A potent peptide agonist of the GLP-1 receptor (Ki = 136 pM) stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma &betaTC-1 cells, supporting efficacy in type 2 diabetes protects

A potent peptide agonist of the GLP-1 receptor (Ki = 136 pM) stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma &betaTC-1 cells, supporting efficacy in type 2 diabetes protects

A potent peptide agonist of the GLP-1 receptor (Ki = 136 pM) stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma &betaTC-1 cells, supporting efficacy in type 2 diabetes protects

A cell-permeable, reversible inhibitor of exocytosis (IC₅₀ = 20 &microM) interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum by dissociating the GTPase activator ARF1 from Golgi

A cell-permeable, reversible inhibitor of exocytosis (IC₅₀ = 20 &microM) interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum by dissociating the GTPase activator ARF1 from Golgi

Ambroxol is a bronchial expectorant that also exhibits antioxidative activity. Ambroxol stimulates the ciliary beat frequency and increases mucous secretion in the lung and trachea.

Ambroxol is a bronchial expectorant that also exhibits antioxidative activity. Ambroxol stimulates the ciliary beat frequency and increases mucous secretion in the lung and trachea.

Ambroxol is a bronchial expectorant that also exhibits antioxidative activity. Ambroxol stimulates the ciliary beat frequency and increases mucous secretion in the lung and trachea.

A linear pentapeptide that communicating cells produce and release, which upon reaching a sufficient concentration activates the cell death pathway in a subset of cells facilitates mazEF-mediated cell death, significantly reducing population size

A linear pentapeptide that communicating cells produce and release, which upon reaching a sufficient concentration activates the cell death pathway in a subset of cells facilitates mazEF-mediated cell death, significantly reducing population size