Biologically Active Small Molecules

An agonist of dopamine D1A (D1R) and D1B (D5R) receptors (Kds = 17 and 11 nM, respectively) alters hemodynamic properties, including hypertension, in animals.

An agonist of dopamine D1A (D1R) and D1B (D5R) receptors (Kds = 17 and 11 nM, respectively) alters hemodynamic properties, including hypertension, in animals.

An agonist of dopamine D1A (D1R) and D1B (D5R) receptors (Kds = 17 and 11 nM, respectively) alters hemodynamic properties, including hypertension, in animals.

A synthetic retinoid that induces ceramide in tumor cell lines, leading to caspase-dependent apoptosis (IC₅₀ = 2.4 &microM) promotes ROS generation, MCL-1 degradation, and PKC&delta cleavage selectively activates RAR&gamma at 5-20

An inhibitor of ferroptosis (IC₅₀ = 60 nM), a specific type of non-apoptotic, iron-dependent, oxidative cell death prevents ferroptosis in cancer cells and inhibits cell death in cell models of Huntington&rsquos disease, periventricular

An inhibitor of ferroptosis (IC₅₀ = 60 nM), a specific type of non-apoptotic, iron-dependent, oxidative cell death prevents ferroptosis in cancer cells and inhibits cell death in cell models of Huntington&rsquos disease, periventricular

An inhibitor of ferroptosis (IC₅₀ = 60 nM), a specific type of non-apoptotic, iron-dependent, oxidative cell death prevents ferroptosis in cancer cells and inhibits cell death in cell models of Huntington&rsquos disease, periventricular

A prenylated 4-hydroxycoumarin with potent activity against mycobacteria stimulates tubulin polymerization and is cytotoxic to various human tumor cell lines disrupts oxidative phosphorylation, inhibiting succinate ubiquinone reductase.

A prenylated 4-hydroxycoumarin with potent activity against mycobacteria stimulates tubulin polymerization and is cytotoxic to various human tumor cell lines disrupts oxidative phosphorylation, inhibiting succinate ubiquinone reductase.

A prenylated 4-hydroxycoumarin with potent activity against mycobacteria stimulates tubulin polymerization and is cytotoxic to various human tumor cell lines disrupts oxidative phosphorylation, inhibiting succinate ubiquinone reductase.

A lipophilic derivative of ferulic acid, with increased ability to cross cell membranes less DPPH radical scavenging capacity than ferulic acid (IC50 = 66.7 &muM for FAEE vs.

A lipophilic derivative of ferulic acid, with increased ability to cross cell membranes less DPPH radical scavenging capacity than ferulic acid (IC50 = 66.7 &muM for FAEE vs.