Biologically Active Small Molecules

AGDV is a C-terminal peptide sequence found on fibrinogen that is known as a binding site for glycoprotein IIb/IIIa (integrin aIIbß3) this binding is required for platelet adhesion and aggregation.

AGDV is a C-terminal peptide sequence found on fibrinogen that is known as a binding site for glycoprotein IIb/IIIa (integrin aIIbß3) this binding is required for platelet adhesion and aggregation.

AGDV is a C-terminal peptide sequence found on fibrinogen that is known as a binding site for glycoprotein IIb/IIIa (integrin aIIbß3) this binding is required for platelet adhesion and aggregation.

A natural macrocyclic antibiotic that inhibits RNA polymerase with selectivity for Gram-positive bacteria over Gram-negative bacteria (IC₅₀s = 0.4 and 6 &muM, respectively) has potent antibacterial activity against most Gram-positive

A natural macrocyclic antibiotic that inhibits RNA polymerase with selectivity for Gram-positive bacteria over Gram-negative bacteria (IC₅₀s = 0.4 and 6 &muM, respectively) has potent antibacterial activity against most Gram-positive

A natural macrocyclic antibiotic that inhibits RNA polymerase with selectivity for Gram-positive bacteria over Gram-negative bacteria (IC₅₀s = 0.4 and 6 &muM, respectively) has potent antibacterial activity against most Gram-positive

An FGFR inhibitor.

An FGFR inhibitor.

An FGFR inhibitor.

An FGFR inhibitor.

A selective inhibitor of JAK1 (IC₅₀ = 629 nM) that displays 30-fold selectivity for JAK1- over JAK2-dependent signaling in human whole blood blocks IL-6/STAT1 and IL-2/STAT5 signaling in cell models and whole blood assays.

A selective inhibitor of JAK1 (IC₅₀ = 629 nM) that displays 30-fold selectivity for JAK1- over JAK2-dependent signaling in human whole blood blocks IL-6/STAT1 and IL-2/STAT5 signaling in cell models and whole blood assays.