Biologically Active Small Molecules

A selective inhibitor of JAK1 (IC₅₀ = 629 nM) that displays 30-fold selectivity for JAK1- over JAK2-dependent signaling in human whole blood blocks IL-6/STAT1 and IL-2/STAT5 signaling in cell models and whole blood assays.

A fluorescent molecule that can be used to detect cholesterol by fluorescence and freeze-fracture electron microscopy.

A fluorescent molecule that can be used to detect cholesterol by fluorescence and freeze-fracture electron microscopy.

A fluorescent molecule that can be used to detect cholesterol by fluorescence and freeze-fracture electron microscopy.

A 4-azasteroid analog of testosterone that competitively blocks type II 5&alpha-reductase activity (IC₅₀ = 4.2 nM) with 100-fold greater affinity than for the type I enzyme used in the treatment of benign prostatic hyperplasia,

A 4-azasteroid analog of testosterone that competitively blocks type II 5&alpha-reductase activity (IC₅₀ = 4.2 nM) with 100-fold greater affinity than for the type I enzyme used in the treatment of benign prostatic hyperplasia,

A 4-azasteroid analog of testosterone that competitively blocks type II 5&alpha-reductase activity (IC₅₀ = 4.2 nM) with 100-fold greater affinity than for the type I enzyme used in the treatment of benign prostatic hyperplasia,

A structural analog of sphingosine that is phosphorylated in vivo to form fingolimod-phosphate, which functions as an agonist at S1P1, S1P4, and S1P5 receptors (EC50 = ~0.3-0.

A structural analog of sphingosine that is phosphorylated in vivo to form fingolimod-phosphate, which functions as an agonist at S1P1, S1P4, and S1P5 receptors (EC50 = ~0.3-0.

A structural analog of sphingosine that is phosphorylated in vivo to form fingolimod-phosphate, which functions as an agonist at S1P1, S1P4, and S1P5 receptors (EC50 = ~0.3-0.

A structural analog of sphingosine that is phosphorylated in vivo to form fingolimod-phosphate, which functions as an agonist at S1P1, S1P4, and S1P5 receptors (EC50 = ~0.3-0.

A derivative of halopemide which potently inhibits both PLD1 (IC₅₀ = 25 nM) and PLD2 (IC₅₀ = 20 nM) prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis.