Biologically Active Small Molecules

1,4-Benzoquinone is a precursor used in the synthesis of hydroquinone and is also used as a hydrogen acceptor and oxidant. 1,4-Benzoquinone exhibits anti-inflammatory and antibiotic activities.

A competitive inhibitor of HIF prolyl 4-hydroxylase (IC₅₀ = 2.4-3.6 &microM).

A competitive inhibitor of HIF prolyl 4-hydroxylase (IC₅₀ = 2.4-3.6 &microM).

A competitive inhibitor of HIF prolyl 4-hydroxylase (IC₅₀ = 2.4-3.6 &microM).

A competitive inhibitor of HIF prolyl 4-hydroxylase (IC₅₀ = 2.4-3.6 &microM).

1,4-PBIT is a potent inhibitor of purified human iNOS and nNOS with Ki values of 7.4 and 16 nM, respectively, compared to a Ki of 360 nM for human eNOS. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.

1,4-PBIT is a potent inhibitor of purified human iNOS and nNOS with Ki values of 7.4 and 16 nM, respectively, compared to a Ki of 360 nM for human eNOS. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.

1,4-PBIT is a potent inhibitor of purified human iNOS and nNOS with Ki values of 7.4 and 16 nM, respectively, compared to a Ki of 360 nM for human eNOS. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.

1,4-PBIT is a potent inhibitor of purified human iNOS and nNOS with Ki values of 7.4 and 16 nM, respectively, compared to a Ki of 360 nM for human eNOS. Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.

An inhibitor of poly(ADP-ribose) synthetase (PARP1 IC₅₀ = 0.39 &muM) can be used with cells in culture and in animals.

An inhibitor of poly(ADP-ribose) synthetase (PARP1 IC₅₀ = 0.39 &muM) can be used with cells in culture and in animals.

An inhibitor of poly(ADP-ribose) synthetase (PARP1 IC₅₀ = 0.39 &muM) can be used with cells in culture and in animals.