LACTACYSTIN

Catalog No.: C005B-456013
Mfr. No.: L6785-.2MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 0.2
UOM: MG

Price: $888.77

List Price: $987.53

General description Lactacystin is an antibiotic :and a metabolite of Streptomyces :spp. Application Lactacystin has been used: as a proteasome inhibitor to inhibit protein degradation to inhibit proteasomal activity of cells for

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Description
Specifications

General description

Lactacystin is an antibiotic and a metabolite of Streptomyces spp.

Application

Lactacystin has been used:

as a proteasome inhibitor to inhibit protein degradation
to inhibit proteasomal activity of cells for live cell imaging
to block proteasomal proteolysis in human monocyte-derived dendritic cells (MoDCs) for 24 h
to provide unilateral injection to animals to induce nigrostriatal lesions

Biochem/physiol Actions

Lactacystin can block the development of cell cycle and stimulate differentiation in a murine neuroblastoma cell line. It can serve as a precursor for clasto-lactacystin β-lactone. Cell-permeable and irreversible proteasome inhibitor (Ki = 4nM). Inhibits NF-kB activation (IC50 = 10mM). Induces neurite outgrowth in neuro2A mouse neuroblastoma cells.

UPC:: 51284013
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: L6785-.2MG
CAS:: 133343-34-7

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