Lapaquistat (C09-1142-574)

Lapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of Lapaquistat acetate ( HY-16274 ). Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapyIn VitroLapaquistat inhibits cholesterol biosynthesis in differentiated RD (rhabdomyosarcoma) cells, with an IC 50 of 36 nM. Lapaquistat potently inhibits cholesterol synthesis in RD cells, with an IC 25 exceeded 100 μM. Lapaquistat concentration-dependently inhibits cholesterol biosynthesis in human skeletal myocytes, with an IC 50 of 45 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoAfter oral administration to rats, Lapaquistat acetate (HY-16274) is absorbed and rapidly hydrolyzed into a pharmacological active metabolite, Lapaquistat . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Cholesterol biosynthesis. Molecular Formula: C31H39ClN2O8 Molecular Weight: 603.1 PubChem CID: 9960389 Isomeric SMILES: CC(C)(CN1C2=C(C=C(C=C2)Cl)[C@H](O[C@@H](C1=O)CC(=O)N3CCC(CC3)CC(=O)O)C4=C(C(=CC=C4)OC)OC)CO