LAQ824 (NVP-LAQ824) is a novel HDAC inhibitor with IC|50|of 32 nM. LAQ824 activates the p21 promoter with 50% of the maximal promoter activation (AC|50|) of 0.30 μM, which in turn, activates the p21 inhibitor gene. LAQ824 inhibits the cell growth of H1299, a non-small cell lung carcinoma line, and HCT116, a colon cancer cell line with IC|50|of 0.15 μM and 0.01 μM, respectively. A recent study shows that LAQ824 induces chromatin changes at the level of the IL-10 gene promoter that lead to enhanced recruitment of the transcriptional repressors HDAC11 and PU.1 and inhibits IL-10 production in BALB/c murine macrophages. Specification: 0.98 Molecular Formula: C22H25N3O3 Molecular Weight: 379.45 PubChem CID: 6445533 Isomeric SMILES: C1=CC=C2C(=C1)C(=CN2)CCN(CCO)CC3=CC=C(C=C3)/C=C/C(=O)NO Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/L338041-SCI_be580caecef47e2ec6af7c60a985c962.pdf
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- L338041-100mg
- CAS:
- 404951-53-7
- Product Size:
- 100mg
- Hazard Statement Codes:
- H315:H319:H335
- Precautionary Statement Codes:
- P261:P264:P271:P280
