LatanoprostAcid (C09-0932-710)

Latanoprost (free acid) is a metabolite of Latanoprost, an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as an FP receptor ligand for the human recombinant FP receptor. Latanoprost is the isopropyl ester of a PGF2α analog containing an aromatic group (17-phenyl) in the ω-chain. Lat-FA is the corresponding carboxylic acid of this analog. Lat-FA is a potent FP receptor agonist with an EC50 of 3.6 nM for human FP receptors, which is twice the potency of PGF2α. Therefore making Latanoprost (free acid) is an activator of PGF2αR.An F-series prostaglandin (PG) analog. Specification: ≥98% MDL Number: MFCD08056084 Molecular Formula: C23H34O5 Molecular Weight: 390.51 EC Number: 682-021-0 PubChem CID: 6441636 Isomeric SMILES: C1[C@H]([C@@H]([C@H]([C@H]1O)C/C=C/CCCC(=O)O)CC[C@H](CCC2=CC=CC=C2)O)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/L133844-SCI_07b07f848d03c5d4eb2d644654495a9b.pdf