General description
A structurally unique marine toxin. Inhibits actin polymerization in vitro and disrupts microfilament organization as well as microfilament-mediated processes. 10 to 100-fold more potent than cytochalasins.
A structurally unique marine toxin. Inhibits actin polymerization in vitro and disrupts microfilament organization as well as microfilament-mediated processes; 10 to 100-fold more potent than cytochalasins.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Actin polymerization
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Harmful (C)
Other Notes
Spector, I., et al. 1989. Cell Motil. Cytoskeleton13, 127.
de Oliveira, C.A., and Mantovani, B. 1988. Life Sci.43, 1825.
Coue, M., et al. 1987. FEBS Lett.213, 316.
Spector, I., et al. 1983. Science219, 493.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51111754
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- 428020-5MG
- CAS:
- 76343-94-7
