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lgk 974 (c09-0934-664)

LGK 974 (C09-0934-664)

Aladdin

Catalog No.
C09-0934-664
Manufacturer No.
L340659-5mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA
Price: $176.85
List Price: $196.50

LGK 974 is a potent and specific small molecule Porcupine (PORCN) inhibitor. Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of

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LGK 974 is a potent and specific small molecule Porcupine (PORCN) inhibitor. Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. LGK 974 greatly reduces Wnt secretion without decreasing its synthesis and without increasing cytotoxicity. LGK 974 is orally bioavailable in mice and induces tumor regression in mouse breast tumors produced by mammary tumor virus-driven Wnt1 signaling. Interestingly, it can also block carcinogenesis in other Wnt-related tumors at doses that have limited impact on stem cell renewal. Specification: 0.98 Molecular Formula: C23H20N6O Molecular Weight: 396.4 PubChem CID: 46926973 Isomeric SMILES: CC1=CC(=CN=C1C2=CC(=NC=C2)C)CC(=O)NC3=NC=C(C=C3)C4=NC=CN=C4 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/L340659-SCI_81b842e4300f395d1c846427a290e8a6.pdf
UPC:
12352005
Condition:
New
Availability:
1 day
Weight:
0.96 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
L340659-5mg
CAS:
1243244-14-5
Product Size:
5mg
Precautionary Statement Codes:
P264


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