ligands acting on targets

Misoprostol is a widely sold analog of prostaglandin E1 (PGE1) which has potent but relatively non-selective agonist activity with respect to the prostanoid EP receptor subgroup.(1) Misoprostol has been used therapeutically for many years in humans

Misoprostol is a widely sold analog of prostaglandin E1 (PGE1) which has potent but relatively non-selective agonist activity with respect to the prostanoid EP receptor subgroup.(1) Misoprostol has been used therapeutically for many years in humans

11β-Prostaglandin E1 (11β-PGE1) is an epimerized form of PGE1 at the C-11 position. Multiple studies have shown that 11β-PGE1 is less potent than the isomer PGE1.

11β-Prostaglandin E1 (11β-PGE1) is an epimerized form of PGE1 at the C-11 position. Multiple studies have shown that 11β-PGE1 is less potent than the isomer PGE1.

11β-PGE2 is the C-11 epimer of PGE2 and is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a K|i|= 53 nM. 11β-PGE2 has been shown to stimulate bone resorption in rats and to inhibit PGE2 binding to the prostaglandin

11β-PGE2 is the C-11 epimer of PGE2 and is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a K|i|= 53 nM. 11β-PGE2 has been shown to stimulate bone resorption in rats and to inhibit PGE2 binding to the prostaglandin

The stereoisomer of PGF1α with both C-9 and C-11 hydroxyls inverted (β), yet there are no published reports on the biological activity.

The stereoisomer of PGF1α with both C-9 and C-11 hydroxyls inverted (β), yet there are no published reports on the biological activity.

11β-Prostaglandin F2α Ethanolamide is believed to be a hepatic metabolite of COX-2 degradation of PGD2-EA. PGD2-EA is formed in activated RAW 264.7 cells treated with AEA , an endogenous cannabinoid found in brain, liver, and other mammalian tissues.

11β-Prostaglandin F2α Ethanolamide is believed to be a hepatic metabolite of COX-2 degradation of PGD2-EA. PGD2-EA is formed in activated RAW 264.7 cells treated with AEA , an endogenous cannabinoid found in brain, liver, and other mammalian tissues.

12(R)-HETE is an arachidonic acid metabolite synthesized in the 12-lipoxygenase pathway in platelets and macrophages. Studies suggest that 12(R)-HETE is a better stimulator of leukocyte aggregation and enhances leukocyte chemokinesis better than its

12(S),20-DiHETE, an arachidonic acid metabolite, has been demonstrated to be formed from 12-hydroxyeicosatetraenoic acid (12-HETE: sc-204982) during interaction between platelets and unstimulated neutrophils. This formation has been shown to be