ligands acting on targets

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15-deoxy-LXA4.

15-deoxy-LXA4.

15-deoxy-TIC.

15-deoxy-TIC.

15-deoxy-Δ12,14-PGA2 is a synthetic analog of PGA2. It shares common structural features with 15-deoxy-Δ12,14-PGJ2, which is a ligand for PPARγ. Antitumor and antimitotic activity have been reported for a similar analog, but there are no published

15-deoxy-Δ12,14-PGA2 is a synthetic analog of PGA2. It shares common structural features with 15-deoxy-Δ12,14-PGJ2, which is a ligand for PPARγ. Antitumor and antimitotic activity have been reported for a similar analog, but there are no published

A synthetic analog of PGD|2|and a potential precursor to the PPARγ ligand 15-deoxy-Δ12,14-PGJ2.1 Exhibits cytotoxic effects on L1210 murine leukemia cells in vitro. 15-deoxy-Δ12,14-PGD|2|is 10-fold more potent than PGD|2|in this activity.2 However,

A synthetic analog of PGD|2|and a potential precursor to the PPARγ ligand 15-deoxy-Δ12,14-PGJ2.1 Exhibits cytotoxic effects on L1210 murine leukemia cells in vitro. 15-deoxy-Δ12,14-PGD|2|is 10-fold more potent than PGD|2|in this activity.2 However,

Formed from PGD2 by the elimination of two molecules of water. Binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.1,2 More potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50

Formed from PGD2 by the elimination of two molecules of water. Binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.1,2 More potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50

15-deoxy-Δ|12,14|-Prostaglandin J|2|is one of the cyclopentenone PGs, which have documented metabolic (peroxisome proliferator-activated receptor γ-activating), antimitotic, and antiproliferative effects.(1,2,3) The activity of the compounds in this