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D649991-25mgDSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase ( Pf DHODH ) with an IC 50 of 8.9 nM. DSM265 can also inhibit the growth of Pf 3D7 parasites with an EC 50 of 4.3 nMIn VivoDSM265 (0.5 to 75 mg/kg: Oral
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D649991-500mgDSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase ( Pf DHODH ) with an IC 50 of 8.9 nM. DSM265 can also inhibit the growth of Pf 3D7 parasites with an EC 50 of 4.3 nMIn VivoDSM265 (0.5 to 75 mg/kg: Oral
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D649991-50mgDSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase ( Pf DHODH ) with an IC 50 of 8.9 nM. DSM265 can also inhibit the growth of Pf 3D7 parasites with an EC 50 of 4.3 nMIn VivoDSM265 (0.5 to 75 mg/kg: Oral
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D649991-5mgDSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase ( Pf DHODH ) with an IC 50 of 8.9 nM. DSM265 can also inhibit the growth of Pf 3D7 parasites with an EC 50 of 4.3 nMIn VivoDSM265 (0.5 to 75 mg/kg: Oral
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D656088-1mlDSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase ( Pf DHODH ) with an IC 50 of 8.9 nM. DSM265 can also inhibit the growth of Pf 3D7 parasites with an EC 50 of 4.3 nMIn VivoDSM265 (0.5 to 75 mg/kg: Oral
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D656251-1mlDSM502 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM502 exhibits nanomolar potency againsts Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHsIn VitroDSM502 shows inhibitory activity against P.
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D647621-10mgDSP-1053, a benzylpiperidine derivative, is a potent Serotonin Transporter (SERT) inhibitor with a K i of 1.02 nM. DSP-1053 shows partial 5-HT 1A receptor agonistic activity with a K i of 5.05 nM. DSP-1053 has antidepressant
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D647621-5mgDSP-1053, a benzylpiperidine derivative, is a potent Serotonin Transporter (SERT) inhibitor with a K i of 1.02 nM. DSP-1053 shows partial 5-HT 1A receptor agonistic activity with a K i of 5.05 nM. DSP-1053 has antidepressant
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D655107-1mlDSP-1053, a benzylpiperidine derivative, is a potent Serotonin Transporter (SERT) inhibitor with a K i of 1.02 nM. DSP-1053 shows partial 5-HT 1A receptor agonistic activity with a K i of 5.05 nM. DSP-1053 has antidepressant activityIC50&:
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D648143-100mgDSR-141562 is a novel, orally active, and selective brain-penetrant phosphodiesterase 1 (PDE1) inhibitor. DSR-141562 shows preferential selectivity for human PDE1B with an IC 50 of 43.9 nM, and the IC 50 values for human PDE1A and 1C are 97.6 and
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D648143-10mgDSR-141562 is a novel, orally active, and selective brain-penetrant phosphodiesterase 1 (PDE1) inhibitor. DSR-141562 shows preferential selectivity for human PDE1B with an IC 50 of 43.9 nM, and the IC 50 values for human PDE1A and 1C are 97.6 and
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D648143-50mgDSR-141562 is a novel, orally active, and selective brain-penetrant phosphodiesterase 1 (PDE1) inhibitor. DSR-141562 shows preferential selectivity for human PDE1B with an IC 50 of 43.9 nM, and the IC 50 values for human PDE1A and 1C are 97.6 and