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G649232-50mgGNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor, with IC 50 s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA, respectively.In VitroHematopoietic progenitor
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G649232-5mgGNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor, with IC 50 s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA, respectively.In VitroHematopoietic progenitor
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G655762-1mlGNE-1858 is a potent and ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor, with IC 50 s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA, respectively.In VitroHematopoietic progenitor
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G646818-10mgGNE-207 is a potent, selective and orally bioavailable inhibitor of the bromodomain of CBP , with an IC 50 of 1 nM, exhibits a selectively index of >:2500-fold against BRD4 (1). GNE-207 shows excellent CBP potency, with an EC 50 of 18 nM for MYC
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G646818-1mgGNE-207 is a potent, selective and orally bioavailable inhibitor of the bromodomain of CBP , with an IC 50 of 1 nM, exhibits a selectively index of >:2500-fold against BRD4 (1). GNE-207 shows excellent CBP potency, with an EC 50 of 18 nM for MYC
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G646818-5mgGNE-207 is a potent, selective and orally bioavailable inhibitor of the bromodomain of CBP , with an IC 50 of 1 nM, exhibits a selectively index of >:2500-fold against BRD4 (1). GNE-207 shows excellent CBP potency, with an EC 50 of 18 nM for MYC
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G647516-100mgGNE-272 is a potent and selective CBP/EP300 inhibitor with IC 50 values of 0.02, 0.03 and 13 μM for CBP, EP300 and BRD4 , respectively. GNE-272 is also a selective in vivo probe for CBP/EP300In VitroGNE-272 is exquisitely selective for CBP/ EP300
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G647516-10mgGNE-272 is a potent and selective CBP/EP300 inhibitor with IC 50 values of 0.02, 0.03 and 13 μM for CBP, EP300 and BRD4 , respectively. GNE-272 is also a selective in vivo probe for CBP/EP300In VitroGNE-272 is exquisitely selective for CBP/ EP300
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G647516-2mgGNE-272 is a potent and selective CBP/EP300 inhibitor with IC 50 values of 0.02, 0.03 and 13 μM for CBP, EP300 and BRD4 , respectively. GNE-272 is also a selective in vivo probe for CBP/EP300In VitroGNE-272 is exquisitely selective for CBP/ EP300
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G647516-50mgGNE-272 is a potent and selective CBP/EP300 inhibitor with IC 50 values of 0.02, 0.03 and 13 μM for CBP, EP300 and BRD4 , respectively. GNE-272 is also a selective in vivo probe for CBP/EP300In VitroGNE-272 is exquisitely selective for CBP/ EP300
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G647516-5mgGNE-272 is a potent and selective CBP/EP300 inhibitor with IC 50 values of 0.02, 0.03 and 13 μM for CBP, EP300 and BRD4 , respectively. GNE-272 is also a selective in vivo probe for CBP/EP300In VitroGNE-272 is exquisitely selective for CBP/ EP300
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G655063-1mlGNE-272 is a potent and selective CBP/EP300 inhibitor with IC 50 values of 0.02, 0.03 and 13 μM for CBP, EP300 and BRD4 , respectively. GNE-272 is also a selective in vivo probe for CBP/EP300In VitroGNE-272 is exquisitely selective for CBP/ EP300