Activin and Inhibin

HJB97 is a high-affinity BET inhibitor with K i s of 0.9 nM ( BRD2 BD1 ), 0.27 nM ( BRD2 BD2 ), 0.18 nM ( BRD3 BD1 ), 0.21 nM ( BRD3 BD2 ), 0.5 nM ( BRD4 BD1 ), 1.0 nM ( BRD4 BD2 ), respectively. HJB97 is employed for the design of potential PROTAC

HKB99 is an allosteric inhibitor of phosphoglycerate mutase 1 ( PGAM1 ). HKB99 inhibits the formation of invasive pseudopodia and increases the level of PAI-2 in vitro. HKB99 increases the oxidative stress, activates JNK/c-Jun and suppresses AKT and

HKB99 is an allosteric inhibitor of phosphoglycerate mutase 1 ( PGAM1 ). HKB99 inhibits the formation of invasive pseudopodia and increases the level of PAI-2 in vitro. HKB99 increases the oxidative stress, activates JNK/c-Jun and suppresses AKT and

HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activityIn VitroHM03 (0.1-50 μM: 72 hours) exhibits over 50% inhibition at 25 μM concentration in HCT116 cells. ?/nHM03 forms

HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activityIn VitroHM03 (0.1-50 μM: 72 hours) exhibits over 50% inhibition at 25 μM concentration in HCT116 cells. ?/nHM03 forms

HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activityIn VitroHM03 (0.1-50 μM: 72 hours) exhibits over 50% inhibition at 25 μM concentration in HCT116 cells. ?/nHM03 forms

HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activityIn VitroHM03 (0.1-50 μM: 72 hours) exhibits over 50% inhibition at 25 μM concentration in HCT116 cells. ?/nHM03 forms

HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activityIn VitroHM03 (0.1-50 μM: 72 hours) exhibits over 50% inhibition at 25 μM concentration in HCT116 cells. ?/nHM03 forms

hMAO-B-IN-4 (compound B10) is a selective, reversible and blood–brain barrier (BBB) penetrable human monoamine oxidase-B ( hMAO-B ) inhibitor with an IC 50 value and a K i value of 0.067 and 0.03 μM, respectively. hMAO-B-IN-4 inhibits hMAO-A with an

hMAO-B-IN-4 (compound B10) is a selective, reversible and blood–brain barrier (BBB) penetrable human monoamine oxidase-B ( hMAO-B ) inhibitor with an IC 50 value and a K i value of 0.067 and 0.03 μM, respectively. hMAO-B-IN-4 inhibits hMAO-A with an

hMAO-B-IN-4 (compound B10) is a selective, reversible and blood–brain barrier (BBB) penetrable human monoamine oxidase-B ( hMAO-B ) inhibitor with an IC 50 value and a K i value of 0.067 and 0.03 μM, respectively. hMAO-B-IN-4 inhibits hMAO-A with an

hMAO-B-IN-4 (compound B10) is a selective, reversible and blood–brain barrier (BBB) penetrable human monoamine oxidase-B ( hMAO-B ) inhibitor with an IC 50 value and a K i value of 0.067 and 0.03 μM, respectively. hMAO-B-IN-4 inhibits hMAO-A with an