Activin and Inhibin

K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRAS G12C.In VitroK-Ras G12C-IN-4 (4 hours) exhibits IC 50 =0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells. K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC

K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRAS G12C.In VitroK-Ras G12C-IN-4 (4 hours) exhibits IC 50 =0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells. K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC

K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRAS G12C.In VitroK-Ras G12C-IN-4 (4 hours) exhibits IC 50 =0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells. K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC

K134 is a phosphodiesterase 3 ( PDE3 ) inhibitor. The IC 50 s of K134 toward PDE3A , PDE3B , PDE5 , PDE2 and PDE4 are 0.1, 0.28, 12.1, &gt:300 and &gt:300 µM, respectively.In VitroK134 (K-134) inhibits rat platelet aggregation induced by collagen

K134 is a phosphodiesterase 3 ( PDE3 ) inhibitor. The IC 50 s of K134 toward PDE3A , PDE3B , PDE5 , PDE2 and PDE4 are 0.1, 0.28, 12.1, &gt:300 and &gt:300 µM, respectively.In VitroK134 (K-134) inhibits rat platelet aggregation induced by collagen

K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC 50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits

K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC 50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits

K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC 50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits

K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC 50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits

KA2507 is a potent, orally active and selective HDAC6 inhibitor, with an IC 50 of 2.5 nM. KA2507 shows antitumor activities and immune modulatory effects in preclinical modelsIn VitroKA2507 did not inhibit the in vitro proliferation of mouse or

KA2507 is a potent, orally active and selective HDAC6 inhibitor, with an IC 50 of 2.5 nM. KA2507 shows antitumor activities and immune modulatory effects in preclinical modelsIn VitroKA2507 did not inhibit the in vitro proliferation of mouse or

KA2507 is a potent, orally active and selective HDAC6 inhibitor, with an IC 50 of 2.5 nM. KA2507 shows antitumor activities and immune modulatory effects in preclinical modelsIn VitroKA2507 did not inhibit the in vitro proliferation of mouse or