Activin and Inhibin

(1R,2R)-ML-SI3 is a potent inhibitor of both TRPML1 and TRPML2 ( IC 50 values of 1.6 and 2.3 μM) and a weak inhibitor ( IC 50 12.5 μM) of TRPML3Form:SolidIC50&amp: Target:TRPML1 1.6 μM (IC 50 ) TRPML2 2.3 μM (IC 50 ) TRPML3 12.5 μM (IC 50 ).

(1R,2R)-ML-SI3 is a potent inhibitor of both TRPML1 and TRPML2 ( IC 50 values of 1.6 and 2.3 μM) and a weak inhibitor ( IC 50 12.5 μM) of TRPML3Form:SolidIC50&amp: Target:TRPML1 1.6 μM (IC 50 ) TRPML2 2.3 μM (IC 50 ) TRPML3 12.5 μM (IC 50 ).

(1R,2R)-ML-SI3 is a potent inhibitor of both TRPML1 and TRPML2 ( IC 50 values of 1.6 and 2.3 μM) and a weak inhibitor ( IC 50 12.5 μM) of TRPML3Form:SolidIC50&amp: Target:TRPML1 1.6 μM (IC 50 ) TRPML2 2.3 μM (IC 50 ) TRPML3 12.5 μM (IC 50 ).

(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD) (1S,2R)-Alicapistat mitigates the metabolic liability of carbonyl reduction and

(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD) (1S,2R)-Alicapistat mitigates the metabolic liability of carbonyl reduction and

(1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC 50 values of 0.095 μM for Pim1 , 0.522 μM for Pim2 and 0.369 μM for Pim3 .Appearance:SolidIC50&amp: Target:IC50: 0.095 μM

(1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC 50 values of 0.095 μM for Pim1 , 0.522 μM for Pim2 and 0.369 μM for Pim3 .Appearance:SolidIC50&amp: Target:IC50: 0.095 μM

(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) a less active enantiomer of Lanabecestat. Lanabecestat is a potent, orally active and blood-brain barrier penetrating BACE1 inhibitor with a K i of 0.4 nM.Form:Solid.

(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) a less active enantiomer of Lanabecestat. Lanabecestat is a potent, orally active and blood-brain barrier penetrating BACE1 inhibitor with a K i of 0.4 nM.Form:Solid.

(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) a less active enantiomer of Lanabecestat. Lanabecestat is a potent, orally active and blood-brain barrier penetrating BACE1 inhibitor with a K i of 0.4 nM.Form:Solid.

(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) a less active enantiomer of Lanabecestat. Lanabecestat is a potent, orally active and blood-brain barrier penetrating BACE1 inhibitor with a K i of 0.4 nM.Form:Solid.

(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) a less active enantiomer of Lanabecestat. Lanabecestat is a potent, orally active and blood-brain barrier penetrating BACE1 inhibitor with a K i of 0.4 nM.