Antimalarial ligands

Ganaplacide (KAF156) hydrochloride is a first-in-class, orally active imidazolopiperazine antimalarial agent. Ganaplacide hydrochloride is active against a broad range of Plasmodium species, including drug-resistant parasites. Ganaplacide

GNF179 is an optimized 8,8-dimethyl imidazolopiperazine analog that exhibits antimalarial potency ( IC 50 of 4.8 nM against the multidrug resistant strain W2). GNF179 is orally activeIn VitroGNF179 does not rapidly inhibit parasite protein

GNF179 is an optimized 8,8-dimethyl imidazolopiperazine analog that exhibits antimalarial potency ( IC 50 of 4.8 nM against the multidrug resistant strain W2). GNF179 is orally activeIn VitroGNF179 does not rapidly inhibit parasite protein

GNF179 is an optimized 8,8-dimethyl imidazolopiperazine analog that exhibits antimalarial potency ( IC 50 of 4.8 nM against the multidrug resistant strain W2). GNF179 is orally activeIn VitroGNF179 does not rapidly inhibit parasite protein

GNF179 is an optimized 8,8-dimethyl imidazolopiperazine analog that exhibits antimalarial potency ( IC 50 of 4.8 nM against the multidrug resistant strain W2). GNF179 is orally activeIn VitroGNF179 does not rapidly inhibit parasite protein

GNF179 is an optimized 8,8-dimethyl imidazolopiperazine analog that exhibits antimalarial potency ( IC 50 of 4.8 nM against the multidrug resistant strain W2). GNF179 is orally activeIn VitroGNF179 does not rapidly inhibit parasite protein

GNF179 is an optimized 8,8-dimethyl imidazolopiperazine analog that exhibits antimalarial potency ( IC 50 of 4.8 nM against the multidrug resistant strain W2). GNF179 is orally activeIn VitroGNF179 does not rapidly inhibit parasite protein

GSK030.

GSK030.

GSK369796.

GSK369796.

Haemanthamine is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine has pro-