Chemokines

SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant ( K i ) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments.In VitroThe affinity of SCH 546738 binding to

SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant ( K i ) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments.In VitroThe affinity of SCH 546738 binding to

SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant ( K i ) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments.In VitroThe affinity of SCH 546738 binding to

SCH 563705 is a potent and orally available CXCR2 and CXCR1 antagonist, with IC 50 s of 1.3 nM, 7.3 nM and K i s of 1 and 3 nM, respectively.In VitroSCH 563705 (Compound 16) is a potent and orally available CXCR2 and CXCR1 antagonist, with IC 50 s

SCH 563705 is a potent and orally available CXCR2 and CXCR1 antagonist, with IC 50 s of 1.3 nM, 7.3 nM and K i s of 1 and 3 nM, respectively.In VitroSCH 563705 (Compound 16) is a potent and orally available CXCR2 and CXCR1 antagonist, with IC 50 s

SX-517 is a dual CXCR2/1 antagonist, containing boronic acid. SX-517 inhibits CXCL1-induced Ca 2+ flux (IC 50 =38 nM), and antagonizes CXCL8-induced [(35)S]GTPγS binding (IC 50 =60 nM) and ERK1/2 phosphorylation. SX-517 has significant ability for

SX-517 is a dual CXCR2/1 antagonist, containing boronic acid. SX-517 inhibits CXCL1-induced Ca 2+ flux (IC 50 =38 nM), and antagonizes CXCL8-induced [(35)S]GTPγS binding (IC 50 =60 nM) and ERK1/2 phosphorylation. SX-517 has significant ability for

SX-517 is a dual CXCR2/1 antagonist, containing boronic acid. SX-517 inhibits CXCL1-induced Ca 2+ flux (IC 50 =38 nM), and antagonizes CXCL8-induced [(35)S]GTPγS binding (IC 50 =60 nM) and ERK1/2 phosphorylation. SX-517 has significant ability for

SX-517 is a dual CXCR2/1 antagonist, containing boronic acid. SX-517 inhibits CXCL1-induced Ca 2+ flux (IC 50 =38 nM), and antagonizes CXCL8-induced [(35)S]GTPγS binding (IC 50 =60 nM) and ERK1/2 phosphorylation. SX-517 has significant ability for

XCL1

XCL1

XCL1