Interleukins

Rolinsatamab is a potent dual IL-4 and IL-13 inhibitor as a fully humanized bispecific monoclonal antibody. Rolinsatamab chimeric antigen receptor sequence T cell. Rolinsatamab can be used in research of immune diseaseForm:LiquidIC50&amp

SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 possesses anti-COVID-19 activity, targeting M pro (IC 50 of 30 nM).In VivoSDZ 224-015 (0.3-300 μg/kg) potently reduces

SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 possesses anti-COVID-19 activity, targeting M pro (IC 50 of 30 nM).In VivoSDZ 224-015 (0.3-300 μg/kg) potently reduces

SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 possesses anti-COVID-19 activity, targeting M pro (IC 50 of 30 nM).In VivoSDZ 224-015 (0.3-300 μg/kg) potently reduces

Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α , IL-1β , and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC 50 ≈0.3 μM). Semapimod tetrahydrochloride inhibits p38 MAPK

Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α , IL-1β , and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC 50 ≈0.3 μM). Semapimod tetrahydrochloride inhibits p38 MAPK

Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α , IL-1β , and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC 50 ≈0.3 μM). Semapimod tetrahydrochloride inhibits p38 MAPK

Sonelokimab (ALX 0761 M 1095) is a trivalent nanobody comprised of monovalent camelid-derived nanobodies specific to human interleukin (IL)-17A, IL-17F , and human serum albumin VHHs. Sonelokimab has the potential for plaque-type psoriasis

SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 binds with high affinity ( K d =70 nM) to IL-2 and blocks binding to its natural receptor IL-2Rα ( K d =10 nM)In VitroSP4206 binds the WT IL-2, IL-2 variant K35L/M39V, IL-2 variant P65A, and

SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 binds with high affinity ( K d =70 nM) to IL-2 and blocks binding to its natural receptor IL-2Rα ( K d =10 nM)In VitroSP4206 binds the WT IL-2, IL-2 variant K35L/M39V, IL-2 variant P65A, and

SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter

SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter