Ligands of Immunopharmacology

BMS-8 inhibits the PD-1/PD-L1 interaction with IC 50 of 7.2 μM. BMS-8, binds directly to PD-L1 and induces formation of PD-L1 homodimers, which in turn prevents the interaction with PD-1.In VitroBMS-8 tends to have a more stable binding mode with

BMS-8 inhibits the PD-1/PD-L1 interaction with IC 50 of 7.2 μM. BMS-8, binds directly to PD-L1 and induces formation of PD-L1 homodimers, which in turn prevents the interaction with PD-1.In VitroBMS-8 tends to have a more stable binding mode with

BMS-8 inhibits the PD-1/PD-L1 interaction with IC 50 of 7.2 μM. BMS-8, binds directly to PD-L1 and induces formation of PD-L1 homodimers, which in turn prevents the interaction with PD-1.In VitroBMS-8 tends to have a more stable binding mode with

BMS-8 inhibits the PD-1/PD-L1 interaction with IC 50 of 7.2 μM. BMS-8, binds directly to PD-L1 and induces formation of PD-L1 homodimers, which in turn prevents the interaction with PD-1.In VitroBMS-8 tends to have a more stable binding mode with

BMS-8 inhibits the PD-1/PD-L1 interaction with IC 50 of 7.2 μM. BMS-8, binds directly to PD-L1 and induces formation of PD-L1 homodimers, which in turn prevents the interaction with PD-1.In VitroBMS-8 tends to have a more stable binding mode with

BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC 50 of 7.68 nM. BMSpep-57 hydrochloride binds to PD-L1 with K d s of 19 nM and 19.88 nM in MST and SPR assays, respectively.

Bryonolic acid is an active triterpenoid compound with immunomodulatory, anti-inflammatory, antioxidant and anticancer activities .In VitroBryonolic acid exerts anti-allergic activity by inhibiting homologous passive cutaneous anaphylaxis and

Bryonolic acid is an active triterpenoid compound with immunomodulatory, anti-inflammatory, antioxidant and anticancer activities .In VitroBryonolic acid exerts anti-allergic activity by inhibiting homologous passive cutaneous anaphylaxis and

Byakangelicol, isolated from Angelica dahurica , inhibits interleukin-1beta (IL-1beta) -induced prostaglandin E2 (PGE2) release in A549 cells mediated by suppression of cyclooxygenase-2 (COX-2) expression and the activity of COX-2 enzyme.

Byakangelicol, isolated from Angelica dahurica , inhibits interleukin-1beta (IL-1beta) -induced prostaglandin E2 (PGE2) release in A549 cells mediated by suppression of cyclooxygenase-2 (COX-2) expression and the activity of COX-2 enzyme.

Byakangelicol, isolated from Angelica dahurica , inhibits interleukin-1beta (IL-1beta) -induced prostaglandin E2 (PGE2) release in A549 cells mediated by suppression of cyclooxygenase-2 (COX-2) expression and the activity of COX-2 enzyme.

c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second