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N648332-5mgNFATc1-IN-1 (compound A04) is a potent inhibitor of RANKL-induced osteoclast formation, with an IC 50 of 1.57 μM. NFATc1-IN-1 shows anti-osteoclastogenic effects through reducing the RANKL-induced nuclear translocation of NFATc1. NFATc1-IN-1 can be
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N651079-100mgNLRP3-IN-10 is a potent NLRP3 inhibitor, inhibits IL-1β release with an IC 50 value of 251.1 nM. NLRP3-IN-10 suppresses NLRP3 inflammasome activation by attenuating ASC speck formationIn VitroNLRP3-IN-10 (compound 14c) (0.4, 1.6, 6.4 μM 40 min)
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N651079-10mgNLRP3-IN-10 is a potent NLRP3 inhibitor, inhibits IL-1β release with an IC 50 value of 251.1 nM. NLRP3-IN-10 suppresses NLRP3 inflammasome activation by attenuating ASC speck formationIn VitroNLRP3-IN-10 (compound 14c) (0.4, 1.6, 6.4 μM 40 min)
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N651079-25mgNLRP3-IN-10 is a potent NLRP3 inhibitor, inhibits IL-1β release with an IC 50 value of 251.1 nM. NLRP3-IN-10 suppresses NLRP3 inflammasome activation by attenuating ASC speck formationIn VitroNLRP3-IN-10 (compound 14c) (0.4, 1.6, 6.4 μM 40 min)
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N651079-50mgNLRP3-IN-10 is a potent NLRP3 inhibitor, inhibits IL-1β release with an IC 50 value of 251.1 nM. NLRP3-IN-10 suppresses NLRP3 inflammasome activation by attenuating ASC speck formationIn VitroNLRP3-IN-10 (compound 14c) (0.4, 1.6, 6.4 μM 40 min)
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N651079-5mgNLRP3-IN-10 is a potent NLRP3 inhibitor, inhibits IL-1β release with an IC 50 value of 251.1 nM. NLRP3-IN-10 suppresses NLRP3 inflammasome activation by attenuating ASC speck formationIn VitroNLRP3-IN-10 (compound 14c) (0.4, 1.6, 6.4 μM 40 min)
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N648460-100mgNLRP3-IN-11 is a NLR family pyrin domain containing 3 (NLRP3) proteins inhibitor. NLRP3-IN-11 has biological activity for NLRP3 with an IC 50 value of <0.3 μM. NLRP3-IN-11 can be used for the researh of inflammatory and degenerative diseases
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N648460-10mgNLRP3-IN-11 is a NLR family pyrin domain containing 3 (NLRP3) proteins inhibitor. NLRP3-IN-11 has biological activity for NLRP3 with an IC 50 value of <0.3 μM. NLRP3-IN-11 can be used for the researh of inflammatory and degenerative diseases
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N648460-25mgNLRP3-IN-11 is a NLR family pyrin domain containing 3 (NLRP3) proteins inhibitor. NLRP3-IN-11 has biological activity for NLRP3 with an IC 50 value of <0.3 μM. NLRP3-IN-11 can be used for the researh of inflammatory and degenerative diseases
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N648460-50mgNLRP3-IN-11 is a NLR family pyrin domain containing 3 (NLRP3) proteins inhibitor. NLRP3-IN-11 has biological activity for NLRP3 with an IC 50 value of <0.3 μM. NLRP3-IN-11 can be used for the researh of inflammatory and degenerative diseases
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N648460-5mgNLRP3-IN-11 is a NLR family pyrin domain containing 3 (NLRP3) proteins inhibitor. NLRP3-IN-11 has biological activity for NLRP3 with an IC 50 value of <0.3 μM. NLRP3-IN-11 can be used for the researh of inflammatory and degenerative diseases
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N647350-100mgNLRP3-IN-13 is a selective and potent NLRP3 inhibitor ( IC 50 : 2.1 μM). NLRP3-IN-13 inhibits NLRP3 andNLRC4 inflammasomes, and inhibits NLRP3-mediated IL-1β production. NLRP3-IN-13 also inhibits NLRP3 ATPase activity. NLRP3-IN-13 can be used in the