PROTACs, molecular glues and other degraders

NRX-252262 is a potent enhancer of the interaction between β-Catenin , and its cognate E3 ligase , SCF β-TrCP , induces mutant β-catenin degradation, with an EC 50 of 3.8 nMIn VitroNRX-252262 (35 μM) causes S33E/S37A mutant β-catenin degradation in

NRX-252262 is a potent enhancer of the interaction between β-Catenin , and its cognate E3 ligase , SCF β-TrCP , induces mutant β-catenin degradation, with an EC 50 of 3.8 nMIn VitroNRX-252262 (35 μM) causes S33E/S37A mutant β-catenin degradation in

NRX-252262 is a potent enhancer of the interaction between β-Catenin , and its cognate E3 ligase , SCF β-TrCP , induces mutant β-catenin degradation, with an EC 50 of 3.8 nMIn VitroNRX-252262 (35 μM) causes S33E/S37A mutant β-catenin degradation in

Nutlin-C1-amido-PEG4-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Nutlin 3 based MDM2 ligand and 4-unit PEG linker used in PROTAC technology.Appearance:SolidIC50&amp: Target:MDM2Biological

Nutlin-C1-amido-PEG4-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Nutlin 3 based MDM2 ligand and 4-unit PEG linker used in PROTAC technology.Appearance:SolidIC50&amp: Target:MDM2Biological

Nutlin-C1-amido-PEG4-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Nutlin 3 based MDM2 ligand and 4-unit PEG linker used in PROTAC technology.Appearance:SolidIC50&amp: Target:MDM2Biological

NVP-DKY709.

NVP-DKY709.

NX-2127.

NX-2127.

PAC, consists the ADCs linker and PROTACs , conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab).In

PD0325901-O-C2-dioxolane has main portion of MEK inhibitor PD0325901. PD0325901-O-C2-dioxolane and a ligand of VHL or CRBN E3 ligase can be used in the synthesis of MEK1/2 degraderIn VitroPD0325901 is a non-ATP competitive MEK inhibitor, potently