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A126845-5mgA-674563 is an Akt1 inhibitor with Ki of 11 nM in cell-free assays, modest potent to PKA and >:30-fold selective for Akt1 over PKC.A selective Akt1, PKA, and CDK2 inhibitor.
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A127941-10mgA-803467 inhibits spontaneous and evoked action potentials in sensory neurons. It exhibits antinociceptive effects.A-803467 decreases the firing in spinal dorsal horn neurons in vivo.The small molecule A-803467 is a potent and selective Nav1.8
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A127941-50mgA-803467 inhibits spontaneous and evoked action potentials in sensory neurons. It exhibits antinociceptive effects.A-803467 decreases the firing in spinal dorsal horn neurons in vivo.The small molecule A-803467 is a potent and selective Nav1.8
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A127582-100mgA-867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. laevis oocytes). Displays no activity at 5-HT3A, α3β4 or α4β2 nAChRs.