Synthetic organic

AZD0328.

AZD0328.

InformationAZD0364 (ATG-017) AZD0364 (ATG-017) is a pre-clinical ERK1/2 inhibitor with an IC50 of 0.6 nM for ERK2.TargetsERK2 0.6 nMIn vitroAZD0364 exhibits high cellular potency against a direct downstream substrate on the MAPK pathway (e.g.

AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor of GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows &gt:14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.

AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor of GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows &gt:14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.

AZD1152.

AZD1152.

AZD1152.

AZD1152.

AZD1152.

AZD1208 is a potent, and orally available Pim kinase inhibitor with IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively.

AZD1208 is a potent, and orally available Pim kinase inhibitor with IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively.