Synthetic organic

AZD1208 is a potent, and orally available Pim kinase inhibitor with IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively.

AZD1236.

AZD1236.

AZD1332.

AZD1332.

AZD1386.

AZD1386.

InformationAZD1390 is a first-in-class orally available and CNS penetrantATMinhibitor with an IC50 of 0.78 nM in cells and &gt:10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a

InformationAZD1390 is a first-in-class orally available and CNS penetrantATMinhibitor with an IC50 of 0.78 nM in cells and &gt:10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a

InformationAZD1390 is a first-in-class orally available and CNS penetrantATMinhibitor with an IC50 of 0.78 nM in cells and &gt:10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a

InformationAZD1390 is a first-in-class orally available and CNS penetrantATMinhibitor with an IC50 of 0.78 nM in cells and &gt:10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a

AZD1480 has been used as an inhibitor of janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) in an in vitro cell model of upper gastrointestinal adenocarcinoma. It has also been used in combination with bortezomib to