Synthetic organic

AZD5363 potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2.

AZD5363 potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2.

Potent inhibitor of cyclin-dependent kinases.

Potent inhibitor of cyclin-dependent kinases.

Potent inhibitor of cyclin-dependent kinases.

Potent inhibitor of cyclin-dependent kinases.

InformationAZD5582, a novel small-molecule IAP inhibitor, binds potently to the BIR3 domains ofcIAP1,cIAP2, andXIAPwithIC50values of 15, 21, and 15TargetscIAP1 (Cell-free assay): XIAP (Cell-free assay): cIAP2 (Cell-free assay) 15 nM: 15 nM: 21 nMIn

InformationAZD5582, a novel small-molecule IAP inhibitor, binds potently to the BIR3 domains ofcIAP1,cIAP2, andXIAPwithIC50values of 15, 21, and 15TargetscIAP1 (Cell-free assay): XIAP (Cell-free assay): cIAP2 (Cell-free assay) 15 nM: 15 nM: 21 nMIn

AZD5672.

AZD5672.

AZD5718.

AZD5718.