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B414253-5mgInformationBAY-885 is a highly potent and selectiveERK5inhibitor.TargetsERK5In vitroBAY-885 shows potent ERK5 kinase and transcriptional inhibition in the SN12C-MEF2 reporter cell line (IC50 = 115 nM/IC90 = 691 nM) and has no effects on a reporter
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B414279-10mgInformationBAY-985 is a potent and highly selectiveTBK1/IKKεinhibitor. BAY-985 shows high potency towardTBK1(IC50 = 2 nM, low ATP assay: 30 nM, high ATP assay) andIKKε(IC50 = 2 nM), as well as high potency in the mechanistic pIRF3 assay (IC50 = 74
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B414279-1mgInformationBAY-985 is a potent and highly selectiveTBK1/IKKεinhibitor. BAY-985 shows high potency towardTBK1(IC50 = 2 nM, low ATP assay: 30 nM, high ATP assay) andIKKε(IC50 = 2 nM), as well as high potency in the mechanistic pIRF3 assay (IC50 = 74
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B414279-25mgInformationBAY-985 is a potent and highly selectiveTBK1/IKKεinhibitor. BAY-985 shows high potency towardTBK1(IC50 = 2 nM, low ATP assay: 30 nM, high ATP assay) andIKKε(IC50 = 2 nM), as well as high potency in the mechanistic pIRF3 assay (IC50 = 74
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B414279-5mgInformationBAY-985 is a potent and highly selectiveTBK1/IKKεinhibitor. BAY-985 shows high potency towardTBK1(IC50 = 2 nM, low ATP assay: 30 nM, high ATP assay) andIKKε(IC50 = 2 nM), as well as high potency in the mechanistic pIRF3 assay (IC50 = 74
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B414031-100mgInformationBAY 1125976 is a selective allostericAKT1/2inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity ofAKT1(IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP)
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B414031-25mgInformationBAY 1125976 is a selective allostericAKT1/2inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity ofAKT1(IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP)
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B414031-5mgInformationBAY 1125976 is a selective allostericAKT1/2inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity ofAKT1(IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP)
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