Synthetic organic

InformationGDC-0623 (G-868) is a potent and ATP-uncompetitiveMEK1inhibitor withKiof 0.13 nM. Phase 1.TargetsMEK1 0.13 nMIn vitroIn a panel of mutant cancer cell lines, GDC-0623 inhibits cellular proliferation with EC50 of 4 nM, 53 nM, 11 nM, 18 nM

InformationGDC-0623 (G-868) is a potent and ATP-uncompetitiveMEK1inhibitor withKiof 0.13 nM. Phase 1.TargetsMEK1 0.13 nMIn vitroIn a panel of mutant cancer cell lines, GDC-0623 inhibits cellular proliferation with EC50 of 4 nM, 53 nM, 11 nM, 18 nM

GDC-0623.

GDC-0623.

GDC-0834.

GDC-0834.

Potent and selective B-Raf inhibitor.

Potent and selective B-Raf inhibitor.

Potent and selective B-Raf inhibitor.

Potent and selective B-Raf inhibitor.

Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.A potent inhibitor the PI 3-kinase family.

Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.A potent inhibitor the PI 3-kinase family.