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L413873-10mgInformationLifirafenib (BGB-283, Beigene-283) potently inhibitsRAFfamily kinases andEGFRactivities in biochemical assays withIC50values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant.TargetsWT
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L413873-1mgInformationLifirafenib (BGB-283, Beigene-283) potently inhibitsRAFfamily kinases andEGFRactivities in biochemical assays withIC50values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant.TargetsWT
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L413873-25mgInformationLifirafenib (BGB-283, Beigene-283) potently inhibitsRAFfamily kinases andEGFRactivities in biochemical assays withIC50values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant.TargetsWT
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L413873-50mgInformationLifirafenib (BGB-283, Beigene-283) potently inhibitsRAFfamily kinases andEGFRactivities in biochemical assays withIC50values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant.TargetsWT
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L413873-5mgInformationLifirafenib (BGB-283, Beigene-283) potently inhibitsRAFfamily kinases andEGFRactivities in biochemical assays withIC50values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant.TargetsWT
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L288407-100mgGeneral description:A cell-permeable pyrazolylthiazolo-isobutyramide compound that acts as a potent LIM kinase inhibitor (IC50 = 7 and 8 nM against LIMK1 and LIMK2, respectively) and effectively suppresses cellular cofilin phosphorylation (IC50 ~ 1
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L288407-10mgGeneral description:A cell-permeable pyrazolylthiazolo-isobutyramide compound that acts as a potent LIM kinase inhibitor (IC50 = 7 and 8 nM against LIMK1 and LIMK2, respectively) and effectively suppresses cellular cofilin phosphorylation (IC50 ~ 1
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L288407-25mgGeneral description:A cell-permeable pyrazolylthiazolo-isobutyramide compound that acts as a potent LIM kinase inhibitor (IC50 = 7 and 8 nM against LIMK1 and LIMK2, respectively) and effectively suppresses cellular cofilin phosphorylation (IC50 ~ 1
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L288407-50mgGeneral description:A cell-permeable pyrazolylthiazolo-isobutyramide compound that acts as a potent LIM kinase inhibitor (IC50 = 7 and 8 nM against LIMK1 and LIMK2, respectively) and effectively suppresses cellular cofilin phosphorylation (IC50 ~ 1
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L288407-5mgGeneral description:A cell-permeable pyrazolylthiazolo-isobutyramide compound that acts as a potent LIM kinase inhibitor (IC50 = 7 and 8 nM against LIMK1 and LIMK2, respectively) and effectively suppresses cellular cofilin phosphorylation (IC50 ~ 1