Wnt family ligands

HLY78, a Lycorine ( HY-N0288 ) derivative, is a potent activator of the Wnt/β-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6

HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC 50 =27.8 nM ATP inhibition: IC 50 =24.7 nM). HP590 shows anti-proliferative activity to gastric cancer cells and induces apoptosis.Appearance:SolidIC50&amp

HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC 50 =27.8 nM ATP inhibition: IC 50 =24.7 nM). HP590 shows anti-proliferative activity to gastric cancer cells and induces apoptosis.Appearance:SolidIC50&amp

HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC 50 =27.8 nM ATP inhibition: IC 50 =24.7 nM). HP590 shows anti-proliferative activity to gastric cancer cells and induces apoptosis.Appearance:SolidIC50&amp

HSD1590 is potent ROCK inhibitor, with IC 50 s of 1.22 and 0.51 nM for ROCK1 and ROCK2 , respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (K d s&lt2 nM). HSD1590 displays low cytotoxicityIn VitroHSD1590 (0.5-1 µM 24 hours)

HSD1590 is potent ROCK inhibitor, with IC 50 s of 1.22 and 0.51 nM for ROCK1 and ROCK2 , respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (K d s&lt2 nM). HSD1590 displays low cytotoxicityIn VitroHSD1590 (0.5-1 µM 24 hours)

HSD1590 is potent ROCK inhibitor, with IC 50 s of 1.22 and 0.51 nM for ROCK1 and ROCK2 , respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (K d s&lt2 nM). HSD1590 displays low cytotoxicityIn VitroHSD1590 (0.5-1 µM 24 hours)

HSD1590 is potent ROCK inhibitor, with IC 50 s of 1.22 and 0.51 nM for ROCK1 and ROCK2 , respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (K d s&lt2 nM). HSD1590 displays low cytotoxicityIn VitroHSD1590 (0.5-1 µM 24 hours)

HSD1590 is potent ROCK inhibitor, with IC 50 s of 1.22 and 0.51 nM for ROCK1 and ROCK2 , respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (K d s&lt2 nM). HSD1590 displays low cytotoxicityIn VitroHSD1590 (0.5-1 µM 24 hours)

hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1 , with an IC 50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits &gt455-fold selectivity for hSMG-1 over mTOR ( IC 50 =50 nM), PI3Kα/γ ( IC 50 =92/60 nM) and

hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1 , with an IC 50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits &gt455-fold selectivity for hSMG-1 over mTOR ( IC 50 =50 nM), PI3Kα/γ ( IC 50 =92/60 nM) and

Hydrochlorothiazid- 13 C,d 2 is the 13 C- and deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has