Wnt family ligands

IWP-3 is an potent inhibitor of Wnt production with an IC 50 of 40 nM. IWP-3 inhibits Porcupine (Porcn) function thereby blocking palmitoylation of Wnt proteins. IWP-3 inhibits CK1γ3 and CK1ε only moderately and does not inhibit CK1α.

Jagged-1 (188-204) TFA is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human

Jagged-1 (188-204) TFA is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human

Jagged-1 (188-204) TFA is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA , binding to the R site (PKAR), with an EC 50 of 6.5 nM and K d of 8 nM in Trypanosoma brucei . Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA , binding to the R site (PKAR), with an EC 50 of 6.5 nM and K d of 8 nM in Trypanosoma brucei . Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA , binding to the R site (PKAR), with an EC 50 of 6.5 nM and K d of 8 nM in Trypanosoma brucei . Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA , binding to the R site (PKAR), with an EC 50 of 6.5 nM and K d of 8 nM in Trypanosoma brucei . Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA , binding to the R site (PKAR), with an EC 50 of 6.5 nM and K d of 8 nM in Trypanosoma brucei . Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite

JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 ( PHB2 ), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity.In

JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 ( PHB2 ), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity.In

JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 ( PHB2 ), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity.In