Wnt family ligands

SPL-707 is an orally active, selective signal peptide peptidase-like 2a (SPPL2a) inhibitor with an IC 50 of 77 nM for hSPPL2a. SPL-707 inhibits γ-secretase ( IC 50 =6.1 μM) and SPP ( IC 50 =3.7 μM). SPL-707 has the potential for autoimmune diseases

SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effectsIn VitroSRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3,

SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effectsIn VitroSRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3,

SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effectsIn VitroSRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3,

SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effectsIn VitroSRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3,

SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effectsIn VitroSRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3,

SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effectsIn VitroSRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3,

SSTC3 is a casein kinase 1α (CK1α) activator ( K d = 32 nM) that inhibits WNT signaling ( EC 50 = 30 nM). SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors.In VitroSSTC3 (0-1μM, 5 days) decreases the

SSTC3 is a casein kinase 1α (CK1α) activator ( K d = 32 nM) that inhibits WNT signaling ( EC 50 = 30 nM). SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors.In VitroSSTC3 (0-1μM, 5 days) decreases the

SSTC3 is a casein kinase 1α (CK1α) activator ( K d = 32 nM) that inhibits WNT signaling ( EC 50 = 30 nM). SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors.In VitroSSTC3 (0-1μM, 5 days) decreases the

SSTC3 is a casein kinase 1α (CK1α) activator ( K d = 32 nM) that inhibits WNT signaling ( EC 50 = 30 nM). SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors.In VitroSSTC3 (0-1μM, 5 days) decreases the

SSTC3 is a casein kinase 1α (CK1α) activator ( K d = 32 nM) that inhibits WNT signaling ( EC 50 = 30 nM). SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors.In VitroSSTC3 (0-1μM, 5 days) decreases the