Wnt family ligands

Stafib-1 is the first selective inhibitor of the STAT5b SH2 domain, with a K i of 44 nM and an IC 50 of 154 nMIn VitroStafib-1 is the first small molecule which inhibits the STAT5b SH2 domain with more than 50-fold selectivity over STAT5a. MCE has

Stafib-1 is the first selective inhibitor of the STAT5b SH2 domain, with a K i of 44 nM and an IC 50 of 154 nMIn VitroStafib-1 is the first small molecule which inhibits the STAT5b SH2 domain with more than 50-fold selectivity over STAT5a. MCE has

Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b , with an IC 50 of 82 nM and 1.7 μM for STAT5b and STAT5a , respectively. Stafib-2 exhibits poor cell permeabilityIn VitroStafib-2 has an extremely high affinity for

Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b , with an IC 50 of 82 nM and 1.7 μM for STAT5b and STAT5a , respectively. Stafib-2 exhibits poor cell permeabilityIn VitroStafib-2 has an extremely high affinity for

Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b , with an IC 50 of 82 nM and 1.7 μM for STAT5b and STAT5a , respectively. Stafib-2 exhibits poor cell permeabilityIn VitroStafib-2 has an extremely high affinity for

Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b , with an IC 50 of 82 nM and 1.7 μM for STAT5b and STAT5a , respectively. Stafib-2 exhibits poor cell permeabilityIn VitroStafib-2 has an extremely high affinity for

Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b , with an IC 50 of 82 nM and 1.7 μM for STAT5b and STAT5a , respectively. Stafib-2 exhibits poor cell permeabilityIn VitroStafib-2 has an extremely high affinity for

Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b , with an IC 50 of 82 nM and 1.7 μM for STAT5b and STAT5a , respectively. Stafib-2 exhibits poor cell permeabilityIn VitroStafib-2 has an extremely high affinity for

STAT3-IN-11 (7a) is a selective STAT3 inhibitor that inhibits the phosphorylation of STAT3 at site pTyr705 . STAT3-IN-11 inhibits the phosphorylation of downstream genes ( Survivin and Mcl-1 ) without affecting its upstream tyrosine kinases (Src and

STAT3-IN-11 (7a) is a selective STAT3 inhibitor that inhibits the phosphorylation of STAT3 at site pTyr705 . STAT3-IN-11 inhibits the phosphorylation of downstream genes ( Survivin and Mcl-1 ) without affecting its upstream tyrosine kinases (Src and

STAT3-IN-11 (7a) is a selective STAT3 inhibitor that inhibits the phosphorylation of STAT3 at site pTyr705 . STAT3-IN-11 inhibits the phosphorylation of downstream genes ( Survivin and Mcl-1 ) without affecting its upstream tyrosine kinases (Src and

STAT3-IN-11 (7a) is a selective STAT3 inhibitor that inhibits the phosphorylation of STAT3 at site pTyr705 . STAT3-IN-11 inhibits the phosphorylation of downstream genes ( Survivin and Mcl-1 ) without affecting its upstream tyrosine kinases (Src and