Wnt family ligands

ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC 50 of 6 nMForm:SolidIC50&amp Target:IC50: Smo

ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC 50 of 6 nMIC50&amp Target:IC50: Smo

AMG-548 dihydrochloride, an orally active and selective p38α inhibitor ( K i =0.5 nM), shows slightly selective over p38β ( K i =36 nM) and &gt1000 fold selective against p38γ and p38δ . AMG-548 dihydrochloride is also extremely potent in the

AMG-548 dihydrochloride, an orally active and selective p38α inhibitor ( K i =0.5 nM), shows slightly selective over p38β ( K i =36 nM) and &gt1000 fold selective against p38γ and p38δ . AMG-548 dihydrochloride is also extremely potent in the

AMG-548 dihydrochloride, an orally active and selective p38α inhibitor ( K i =0.5 nM), shows slightly selective over p38β ( K i =36 nM) and &gt1000 fold selective against p38γ and p38δ . AMG-548 dihydrochloride is also extremely potent in the

AMG-548 dihydrochloride, an orally active and selective p38α inhibitor ( K i =0.5 nM), shows slightly selective over p38β ( K i =36 nM) and &gt1000 fold selective against p38γ and p38δ . AMG-548 dihydrochloride is also extremely potent in the

AMG-548 dihydrochloride, an orally active and selective p38α inhibitor ( K i =0.5 nM), shows slightly selective over p38β ( K i =36 nM) and &gt1000 fold selective against p38γ and p38δ . AMG-548 dihydrochloride is also extremely potent in the

AMG-548 dihydrochloride, an orally active and selective p38α inhibitor ( K i =0.5 nM), shows slightly selective over p38β ( K i =36 nM) and &gt1000 fold selective against p38γ and p38δ . AMG-548 dihydrochloride is also extremely potent in the

Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC 50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferationIn VitroAngoline (0-100 μM 1 h)

Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima . Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal

Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima . Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal

ARUK3001185 (Compound 8l) is a potent, selective, orally active and brain-penetrant inhibitor of Notum activity with an IC 50 of 6.7 nMForm:SolidIC50&amp Target:IC 50 : 6.7 nM (Notum)