Liproxstatin-1 (C09-0935-596)

InformationLiproxstatin-1 Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.In vitroLiproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4−/−cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4−/−cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H2O2 (200 µM).In vivoLiproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury.Cell Datacell lines：Dendritic cells (DCs) and CD4+ T cellsConcentrations：~200 nMIncubation Time：~72 hPowder Purity:≥97%. Specification: 10mM in DMSO Molecular Formula: C19H21ClN4 Molecular Weight: 340.85